Enantio- and regioselective Heck-type reaction of arylboronic acids with 2,3-dihydrofuran

[GRAPHICS] Reported herein is a protocol for the enantioselective Pd(II)-catalyzed Heck-type reaction between arylboronic acids and 2,3-dihydrofuran. The highest chemical and optical yields were obtained when a Pd(OAc)(2)/(R)-MeO(biphenylphosphine) or a Pd(OAc)(2)/(R)-(2,2'-bis(diphenylphosphino)-1,1'-binaphthyl) catalyst and a Cu(OAc)(2) reoxidant were employed.