Journal
SCIENCE
Volume 316, Issue 5826, Pages 860-866Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1140881
Keywords
-
Categories
Funding
- NCI NIH HHS [R01 CA102142, CA-102142, R01 CA102142-06A1] Funding Source: Medline
Ask authors/readers for more resources
Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop into B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available