Journal
FEBS LETTERS
Volume 581, Issue 10, Pages 2055-2059Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2007.04.040
Keywords
endoplasmic reticulum (ER) stress; ER stress-responsive; alkaline phosphatase (ES-TRAP); transgenic mouse; heavy metal; biosensor
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Endoplasmic reticulum (ER) stress-responsive alkaline phosphatase (ES-TRAP) serves as a sensitive indicator for ER stress. In response to heavy metals including cadmium, nickel and cobalt, hepatocytes and renal tubular cells expressing ESTRAP exhibited ER stress and decreased ES-TRAP activity. In ES-TRAP transgenic mice, acute exposure to cadmium showed rapid, transient decreases in the activity of serum ESTRAP. It was inversely correlated with the induction of endogenous ER stress markers in the liver and kidney. Our result provides first evidence for the acute, reversible induction of ER stress in vivo after exposure to heavy metal. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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