Journal
ONCOGENE
Volume 26, Issue 22, Pages 3227-3239Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1210414
Keywords
signal transduction; MAP kinase; ERK1/2; cell cycle; G1 phase
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The Ras-dependent extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated protein (MAP) kinase pathway plays a central role in cell proliferation control. In normal cells, sustained activation of ERK1/ERK2 is necessary for G1- to S-phase progression and is associated with induction of positive regulators of the cell cycle and inactivation of antiproliferative genes. In cells expressing activated Ras or Raf mutants, hyperactivation of the ERK1/2 pathway elicits cell cycle arrest by inducing the accumulation of cyclin-dependent kinase inhibitors. In this review, we discuss the mechanisms by which activated ERK1/ERK2 regulate growth and cell cycle progression of mammalian somatic cells. We also highlight the findings obtained from gene disruption studies.
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