Journal
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
Volume 230, Issue 10, Pages 1486-1492Publisher
AMER VETERINARY MEDICAL ASSOC
DOI: 10.2460/javma.230.10.1486
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Objective - To determine the impact of successive days of endurance exercise on select serum chemistry values in conditioned Alaskan sled dogs. Design - Prospective cohort study. Animals - 10 conditioned Alaskan sled dogs. Procedures - All dogs ran 160 km/d for 5 consecutive days. Serum was obtained prior to exercise and immediately after each exercise run; all samples were obtained before dogs were fed. Serum electrolyte, mineral, protein, total bilirubin, urea nitrogen, creatinine, and cardiac troponin-I concentrations and serum alkaline phosphatase, alanine aminotransferase, creatine kinase, and aspartate aminotransferase activities were measured. Data were analyzed by means of analysis of covariance for a randomized complete block design with dog as a blocking variable, time as a covariate, and distance run as the treatment of interest. Least square mean values were compared with values obtained prior to exercise, and linear and quadratic contrasts were examined. Results - Serum globulin concentration was low prior to exercise (mean +/- SD, 2.2 +/- 0.3 g/dL) and progressively decreased as exercise continued. Exercise was associated with increases in serum chloride, urea nitrogen, and cardiac troponin-I concentrations and serum alanine aminotransferase, creatine kinase, and aspartate aminotransferase activities and with progressive decreases in serum potassium, total protein, and albumin concentrations. Conclusions and Clinical Relevance - Results suggested that multiple successive days of endurance exercise resulted in mild aberrations in serum chemistry variables in conditioned sled dogs. Changes likely reflected the metabolic stresses of prolonged endurance exercise as well as dietary composition. Hypoglobulinemia in resting, conditioned sled dogs may reflect the immunosuppressive or catabolic effects of intense endurance training.
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