Journal
ONCOGENE
Volume 26, Issue 22, Pages 3267-3278Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1210417
Keywords
NF-kappa B; JNK1; TNF-alpha; UV; signaling; crosstalk
Ask authors/readers for more resources
Integration of the cell signaling circuitry determines the ultimate response of a cell to extracellular stimuli. The transcription factor nuclear factor-kappa B (NF-kappa B) and mitogen-activated protein kinase JNK1 are major players in the cell signaling circuitry, regulating numerous cellular events and being implicated in the process of many human diseases and certain types of cancer. The interplay between NF-kappa B and JNK1 provides a paradigm that shows how the crosstalk between different signaling pathways decides the function of the cell signaling circuitry. Understanding the wiring of the cell signaling circuitry may hold the key for cell signaling-based therapy of human diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available