Journal
JOURNAL OF EXPERIMENTAL BIOLOGY
Volume 210, Issue 10, Pages 1700-1714Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jeb.02716
Keywords
metabolic rate depression; anoxia tolerance; hibernation; reversible protein phosphorylation; signal transduction; stress-induced gene expression; cell cycle arrest; antioxidant defense
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Entry into a hypometabolic state is an important survival strategy for many organisms when challenged by environmental stress, including low oxygen, cold temperatures and lack of food or water. The molecular mechanisms that regulate transitions to and from hypometabolic states, and stabilize long-term viability during dormancy, are proving to be highly conserved across phylogenic lines. A number of these mechanisms were identified and explored using anoxia- tolerant turtles as the model system, particularly from the research contributions made by Dr Peter L. Lutz in his explorations of the mechanisms of neuronal suppression in anoxic brain. Here we review some recent advances in understanding the biochemical mechanisms of metabolic arrest with a focus on ideas such as the strategies used to reorganize metabolic priorities for ATP expenditure, molecular controls that suppress cell functions ( e.g. ion pumping, transcription, translation, cell cycle arrest), changes in gene expression that support hypometabolism, and enhancement of defense mechanisms ( e.g. antioxidants, chaperone proteins, protease inhibitors) that stabilize macromolecules and promote long- term viability in the hypometabolic state.
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