Journal
JOURNAL OF NEUROSCIENCE
Volume 27, Issue 20, Pages 5448-5460Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1186-07.2007
Keywords
desensitization; AMPA; vesicle; reloading; mobilization; latrotoxin
Categories
Funding
- NINDS NIH HHS [R37 NS032405] Funding Source: Medline
Ask authors/readers for more resources
When the synaptic connection between two neurons consists of a small number of release sites, the ability to maintain transmission at high frequencies is limited by vesicle mobilization and by the response of postsynaptic receptors. These two properties were examined at single release sites between granule cells and stellate cells by triggering bursts of quantal events either with alpha-latrotoxin or with high-frequency trains of presynaptic activity. Bursts and evoked responses consisted of tens to hundreds of events with frequencies of up to hundreds per second. This indicates that single release sites can rapidly supply vesicles from a reserve pool to a release-ready pool. In addition, postsynaptic AMPA receptors recover from desensitization with a time constant of similar to 5 ms. Thus, even for synapses composed of a single release site, granule cells can effectively activate stellate cells during sustained high-frequency transmission because of rapid vesicle mobilization and fast recovery of AMPA receptors from desensitization.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available