Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 50, Issue 10, Pages 2516-2519Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm070149m
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- NIAID NIH HHS [AI 34885] Funding Source: Medline
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We disclose here for the first time the curative activity of a new generation of trioxane dimers, designed logically and prepared easily from the natural trioxane artemisinin in only four or five chemical steps that would be easily accomplished also on a manufacturing scale. Four of these trioxane dimers cure malaria-infected mice after only a single subcutaneous dose, and two other dimers cure after three oral doses.
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