Journal
CANCER LETTERS
Volume 250, Issue 1, Pages 1-8Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2006.09.002
Keywords
monocyte; progenitor cell; angiogenesis; integrin; chemokine; endothelial progenitor cell
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Funding
- NCI NIH HHS [R01 CA083133, CA83133, R01 CA126820, R01 CA083133-10, R01 CA083133-11] Funding Source: Medline
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Tumor growth and metastasis depend on neovascularization, the growth of new blood vessels. Recent findings have revealed that tumor neovascularization is regulated in part by monocytes, which are myeloid lineage cells from the bone marrow. Tumors exhibit significant monocyte infiltrates, which are actively recruited to the tumor microenvironment. Upon tumor infiltration, monocytes can participate in tumor neovascularization. Monocytes can either differentiate into macrophages, which express proangiogenic growth factors, or into endothelial-like cells, which may directly participate in neovascularization. Preliminary studies in animals suggest that modulation of bone marrow-derived cell trafficking into tumors will provide a useful new approach in cancer therapy. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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