Journal
FEBS LETTERS
Volume 581, Issue 11, Pages 2156-2161Publisher
WILEY
DOI: 10.1016/j.febslet.2007.01.096
Keywords
autophagy; autophagosome; ATG genes; pre-autophagosomal structure; nutrient starvation
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Autophagy is a degradation process accompanied by dynamic membrane organization. In the yeast, Saccharomyces cerevisiae, about 30 A TG (autophagy-related) genes have been identified as important genes for autophagy. Among them, 17 are indispensable for formation of the autophagosome, an organelle enclosed by a double lipid bilayer during starvation-induced autophagy. Recently, a central structure for autophagosome generation, termed the pre-autophagosomal structure, was identified. Despite intensive study, many questions regarding the mechanisms underlying autophagosome formation remain unanswered. In this review, we will give an overview of recent studies on the mechanisms of autophagosome formation and discuss these unresolved questions. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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