Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 104, Issue 21, Pages 8959-8964Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0702004104
Keywords
autoimmunity; immune homeostasis; immunological tolerance
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Mutations in the gene encoding the transcription factor Foxp3 lead to fatal autoimmune pathology in mice and humans, which is associated with a deficiency in Foxp3(+) regulatory T cells (Trg)- It has also been proposed that Foxp3 inactivation in nonhematopoietic tissues, particularly in thymic epithelium, is required for the pathogenesis, because Foxp3 mutantscurfy bone marrow cells fail to transmit the disease to lethally irradiated WT hosts. We demonstrate here that the lack of pathology in these radiation chimeras is due to the presence of radioresistant enclogenous Foxp3(+) T(reg) Of the host. In addition, chimeras carrying the scurfy mutation only in nonhematopoietic cells exhibit no evidence of autoimmune pathology. Thus, Foxp3 deficiency in nonhematopoietic cells does not contribute to the scurfy disease. Furthermore, our analyses of radiation chimeras revealed that the peripheral T(reg) Pool is fully and specifically restored and maintained by radioresistant enclogenous T(reg) or adoptively transferred exogenous Treg through homeostatic proliferation in the absence of T(reg) production from scurfy donor bone marrow cells. These results thus provide evidence that the autoimmune pathology in scurfy mice results indeed from a T(reg) deficiency and illustrate a robust homeostatic mechanism that strictly controls the size of peripheral Treg pool by fine-tuning of homeostatic proliferation.
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