Journal
FEBS LETTERS
Volume 581, Issue 11, Pages 2112-2118Publisher
WILEY
DOI: 10.1016/j.febslet.2007.01.094
Keywords
vesicular transport; actin; microtubules; dynein; kinesin; myosin
Funding
- NIGMS NIH HHS [R01 GM068674, R01 GM068674-04] Funding Source: Medline
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During vesicular transport, the assembly of the coat complexes and the selection of cargo proteins must be coordinated with the subsequent translocation of vesicles from the donor to an acceptor compartment. Here, we review recent progress toward uncovering the molecular mechanisms that connect transport vesicles to the protein machinery responsible for cytoskeleton-mediated motility. An emerging theme is that vesicle cargo proteins, either directly or through binding interactions with coat proteins, are able to influence cytoskeletal dynamics and motor protein function. Hence, a vesicle's cargo composition may help direct its intracellular motility and targeting. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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