Journal
FEBS LETTERS
Volume 581, Issue 11, Pages 2194-2201Publisher
WILEY
DOI: 10.1016/j.febslet.2007.03.071
Keywords
tunneling nanotube; plasmodesmata; membrane continuity; cell-to-cell communication; intercellular transfer; F-actin
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Recently, highly sensitive nanotubular structures mediating membrane continuity between mammalian cells have been discovered. With respect to their peculiar architecture, these membrane channels were termed tunneling nanotubes (TNTs). TNTs could form de novo between animal cells leading to the generation of complex cellular networks. They have been shown to facilitate the intercellular transfer of organelles as well as, on a limited scale, of membrane components and cytoplasmic molecules. It has been proposed that TNTs represent a novel and general biological principle of cell-to-cell communication and it becomes increasingly apparent that they fulfill important functions in the physiological processes of multicellular organisms. (C) 2007 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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