Journal
VACCINE
Volume 25, Issue 21, Pages 4170-4174Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2007.03.003
Keywords
aerosol measles re-vaccination; antibody responses
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There are no large-scale data on the long-term persistence of measles antibody after vaccination by the aerosol route. We therefore followed-up South African schoolchildren 6 years after their re-vaccination with Edmonston-Zagreb (EZ) and Schwarz (SW) measles vaccine given by aerosol and subcutaneous routes. Measles antibody levels and the proportion of children who were seropositive at year 6 remained significantly higher in the Edmonston-Zagreb aerosol group compared to the groups that received Schwarz or Edmonston-Zagreb vaccine subcutaneously. Measles re-vaccination by aerosol evokes a stronger and much Ion er lasting antibody response than injected vaccine and should thus provide more durable protection against measles. (c) 2007 Elsevier Ltd. All rights reserved.
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