Journal
VIROLOGY
Volume 362, Issue 1, Pages 60-66Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2006.12.018
Keywords
alphaherpesviruses; pseudorabies virus; capping; glycoprotein E; tyrosine phosphorylation; lipid rafts; immunoreceptor
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In specific cell types infected with the alphaherpesviruses herpes simplex virus and pseudorabies virus (PRV), addition of virus-specific antibodies results in redistribution of cell-surface-anchored viral proteins. This redistribution is triggered by the viral protein gE and consists of the directional movement of the antibody-antigen complexes to one pole of the cell. This viral capping process has been associated with increased antibody-resistant virus spread and strongly resembles immunoreceptor capping, a process that is crucial in activation of different immune cells (e.g. capping of Fc gamma-receptors, B and T cell receptors). Here, we report that the PRV gE-mediated viral capping process results in increased Ste kinase-mediated tyrosine phosphorylation of the cytoplasmic domain of gE and that a fraction of gE associates with lipid rafts, all very reminiscent of immunoreceptor capping. These results provide evidence that gE-mediated capping is a viral mimicry of immunoreceptor capping. (C) 2007 Elsevier Inc. All rights reserved.
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