Journal
FEBS LETTERS
Volume 581, Issue 13, Pages 2478-2484Publisher
WILEY
DOI: 10.1016/j.febslet.2007.04.065
Keywords
alpha-KTx3; potassium channels; scorpion toxin; shaker; TEVC; buthus occitanus
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We have purified BoiTx1, the first toxin from the venom of the Israeli scorpion, Buthus occitanus israelis, and studied its activity and genomic organization. BoiTx1 is a 37 amino acid-long peptide contained six conserved cysteines, and is classified as an alpha-KTx3.10 toxin. The pharmacological effects of BoiTx1 were studied on various cloned K+ channels expressed in Xenopus laevis oocytes. BoiTx1 inhibited currents through Drosophila Shaker channels with an IC50 value of 3.5 +/- 0.5 nM, yet had much lesser effect on its mammalian orthologs. Thus, BoiTx1 is the first member of the alpha-KTx3 family that preferentially affects insect potassium channels. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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