Catalytic enantioselective petasis-type reaction of quinolines catalyzed by a newly designed thiourea catalyst

A newly designed thiourea catalyst provides sufficient activation of organoboronic acids to facilitate the enantioselective Petasis transformation of quinolines even at low temperatures. A high degree of stereocontrol was achieved in the reaction of various quinolines and organoboronic acids by using a combination of H2O and NaHCO3 as additives.