Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 129, Issue 21, Pages 6865-6871Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja070713i
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Funding
- NCRR NIH HHS [R01 RR014891, R01 RR014891-02, R01 RR014891-018271, R01 RR014891-01S1, R01 RR014891-01] Funding Source: Medline
- NIBIB NIH HHS [R01 EB000312-04, R01 EB000312-05, R01 EB000312, R01 EB000312-03, R01 EB000312-07, R01 EB000312-06A1, 5-R01-EB000312] Funding Source: Medline
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Peptide-coated quantum dot-photosensitizer conjugates were developed using novel covalent conjugation strategies on peptides which overcoat quantum dots (QDs). Rose bengal and chlorin e6, photosensitizers (PSs) that generate singlet oxygen in high yield, were covalently attached to phytochelatin-related peptides. The photosensitizer-peptide conjugates were subsequently used to overcoat green- and red-emitting CdSe/CdS/ZnS nanocrystals. Generation of singlet oxygen could be achieved via indirect excitation through Forster (fluorescence) resonance energy transfer (FRET) from the nanocrystals to PSs, or by direct excitation of the PSs. In the latter case, by using two color excitations, the conjugate could be simultaneously used for fluorescence imaging and singlet oxygen generation. Singlet oxygen quantum yields as high as 0.31 were achieved using 532-nm excitation wavelengths.
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