Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 270, Issue 1-2, Pages 1-7Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2007.03.001
Keywords
gene regulation; transcriptional activation; SP1 transcription factors
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Funding
- NCRR NIH HHS [G12 RR003034] Funding Source: Medline
- NICHD NIH HHS [HD41749] Funding Source: Medline
- NIGMS NIH HHS [S06GM08248] Funding Source: Medline
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Transcription factor SP1 is a zinc finger protein that has been implicated in regulating the expression of several genes involved in cellular differentiation and embryonic development. The zinc finger region of SP1 transcription factors binds to GC or GT-box elements present in the promoters of a number of male germ cell target genes that are developmentally expressed during spermatogenesis. The glutamine and serine/threonine-rich regions of the SP1 proteins recruit co-regulatory factors to the multi-protein preinitiation complex that are important for mediating transcriptional activation in male germ cells. Studies in our laboratory have identified several alternatively spliced transcripts encoding SP1 isoforms that display stage and cell-type-specific expression profiles in differentiating germ cells in the seminiferous epithelium of the testis. This review summarizes the expression patterns and functional significance of these SP1 transcription factor variants during spermatogenesis. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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