Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 59, Issue 4-5, Pages 249-262Publisher
ELSEVIER
DOI: 10.1016/j.addr.2007.03.015
Keywords
scaffolds; porous; biomimetic; surface modification; drug delivery; tissue regeneration
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Funding
- Ministry of Education, Science & Technology (MoST), Republic of Korea [kaist72] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [R0A-2006-000-10228-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A wide range of polymeric scaffolds have been intensively studied for use as implantable and temporal devices in tissue engineering. Biodegradable and biocompatible scaffolds having a highly open porous structure and good mechanical strength are needed to provide an optimal microenvironment for cell proliferation, migration, and differentiation, and guidance for cellular in-growth from host tissue. A variety of natural and synthetic polymeric scaffolds can be :fabricated in the form of a solid foam, nanofibrous matrix, microsphere, or hydrogel. Biodegradable porous scaffolds can be surface engineered to provide an extracellular matrix mimicking environment for better cell adhesion and tissue in-growth. Furthermore, scaffolds can be designed to :release bioactive molecules, such as growth factors, DNA, or drugs, in a sustained manner to facilitate tissue regeneration. This paper reviews the current status of surface engineered and drug releasing scaffolds for tissue engineering. (c) 2007 Elsevier B.V. All rights reserved.
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