Journal
INORGANICA CHIMICA ACTA
Volume 360, Issue 8, Pages 2851-2856Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2007.01.016
Keywords
anticancer platinum complexes; 2-morpholinoethylamine; synthesis; structure
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A series of novel platinum(II) complexes involving an asymmetric chelating diamine 2-morpholinoethylamine (MPEA) as the carrier, cis-[Pt(MPEA)X-2] (X-2=2Cl(-), oxalate, malonate, 1,1-cyclobutanedicarboxylate (CBDCA), 3-hydroxy-1,1-cyclobutanedicarboxylate (HO-CBDCA)), have been synthesized and characterized by elemental analysis and spectroscopic data along with X-ray crystal structure for a representative complex cis-[Pt(MPEA) (CBDCA)]. The Pt(II) is in a square planar environment and is coordinated by a chelating CBDCA and MPEA in cis position. The complexes with dicarboxylate are quite soluble (>25 mg/ml) and stable in water. The cytotoxicity of the complexes has been assessed in the human lung cancer cell lines A549 and A549/ATCC. One complex, cis-[Pt(MPEA)Cl-2], is more active than carboplatin against both the sensitive and resistant cells, and has less cross-resistance with cisplatin. (C) 2007 Elsevier B.V. All rights reserved.
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