Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 9, Issue 6, Pages 679-687Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2007.1529
Keywords
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Funding
- NHLBI NIH HHS [HL 73048, HL67724, HL67727, HL 59139, HL69020] Funding Source: Medline
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Excessive reactive oxygen species (ROS) play an important role in the development of cardiac hypertrophy. In contrast, antioxidants scavenge ROS, thereby maintaining the reduced environment of cells and inhibiting hypertrophy in the heart. Thioredoxin1 (Trx1) not only functions as a major antioxidant in the heart but also interacts with important signaling molecules and transcription factors, thereby attenuating cardiac hypertrophy. This review will discuss the molecular mechanisms by which Trx1 exerts antihypertrophic effects in the heart.
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