Journal
CELL CYCLE
Volume 6, Issue 11, Pages 1288-1292Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.6.11.4299
Keywords
mRNA-binding protein; mRNA turnover; translational control; ELAV; SIRT1; ProT alpha; Bcl-2; Mcl-1
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Funding
- Intramural NIH HHS Funding Source: Medline
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The RNA-binding protein HuR can stabilize and/ or regulate the translation of target mRNAs, thereby affecting the cellular responses to immune, proliferative, and damaging agents. Here, we discuss emerging evidence that HuR elicits a broad anti-apoptotic function through its influence on the expression of multiple target mRNAs. HuR was previously shown to bind to the mRNA encoding the apoptosome inhibitor prothymosin a (ProT alpha) and enhanced its translation and cytoplasmic abundance. More recently, HuR was shown to increase the stability of a target mRNA encoding the pro-survival deacety lase SIRT1. The discovery that HuR likewise binds to and promotes the expression of mRNAs encoding Bcl-2 and Mcl-1, two major anti-apoptotic effectors, strongly supports HuR's role as a key upstream coordinator of a constitutive pro-survival program.
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