Journal
JOURNAL OF BIOLOGICAL RHYTHMS
Volume 22, Issue 3, Pages 220-232Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0748730407301239
Keywords
sleep-wake transitions; development; REM sleep; hippocampus; learning
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Funding
- NIMH NIH HHS [R01 MH076280, R01 MH060670-08, R01 MH076280-02, R01 MH060670] Funding Source: Medline
- PHS HHS [60670, 76280] Funding Source: Medline
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In this article, we discuss mathematical models that address the control of sleep-wake behavior in the infant and adult rodent and a model that addresses changes in single-cell firing patterns in the hippocampus across wake and rapid eye movement (REM) sleep states. Each of the models describes the dynamics of experimentally identified neuronal components - either the fixing activity of wake-and sleep-promoting neuronal populations or the spiking activity of hippocampal pyramidal neurons. Our discussion of each model illustrates how a mathematical model that describes the temporal dynamics of the modeled neuronal components can reveal specifics about proposed neuronal mechanisms that underlie sleep-wake regulation or sleep-specific firing patterns. For example, the dynamics of the models developed for sleep-wake regulation in the infant rodent lend insight into the involved brain-stem neuronal populations and the evolution of the network during maturation. The results of the model for sleep-wake regulation in the adult rodent suggest distinct properties of the involved neuronal populations and their interactions that account for long-lasting and brief waking bouts. The dynamics of the model for sleep-specific hippocampal neural activity proposes neural mechanisms to account for observed activity changes that can invoke synaptic reorganization associated with learning and memory consolidation.
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