Journal
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
Volume 296, Issue 10, Pages 1501-1508Publisher
WILEY
DOI: 10.1002/ar.22769
Keywords
anoikis; anoikis resistance; autophagic cell death; metastasis; solid tumor
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Funding
- National Natural Science Foundation of China (NSFC) [81071730, 91019012, 31071128]
- Tianjin Municipal Science and Technology Commission (TSTC), China [11JCZDJC18700, 11JCZDJC19000, 13JCQNJC11300]
- High Technology Research and Development Program of China (863 Program) [2012AA020206]
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Macroautophagy or autophagy is a lysosome-dependent process in which enzymatic degradation and recycling of cytosolic components occurred due to stressful conditions. This cellular arrangement imparts anoikis resistance in solid tumors. Anoikis, a special form of apoptosis occurring when cells detach from the extracellular matrix, is a critical mechanism in maintaining tissue homeostasis and development. Anoikis resistance facilitates tumorigenesis and metastasis. However, the complexity of the role of autophagy in tumor is underscored by evidence that autophagy can function as both a pro-survival or pro-death depending on the context and the stimuli, which are likely exploitable for tumor therapy. This review focuses on recent progress in understanding anoikis resistance and autophagy signaling, paying particular attention to its relevance in solid tumor metastasis. Anat Rec, 296:1501-1508, 2013. (c) 2013 Wiley Periodicals, Inc.
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