Journal
ADDICTION BIOLOGY
Volume 12, Issue 2, Pages 173-175Publisher
WILEY
DOI: 10.1111/j.1369-1600.2007.00057.x
Keywords
alcohol; hormonal imprinting; nocistatin; opioids; pain; rat
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In earlier experiments perinatal hormonal imprinting by alcohol decreased the hormone content of immune cells for life. In the present study, both a single day (15% on the third postnatal day) and a long-term treatment schedule of alcohol exposure (3% for 21 days) of dams during lactation significantly (P < 0.01) enhanced endogenous levels of nocistatin in the blood plasma as well as in the cerebrospinal fluid of the offspring, measured in 3-month-old rats. Our data suggest that alcohol consumption during lactation can cause a life-long influence on nocistatin levels in the offspring and most likely modify nocistatin-related functions such as pain tolerance.
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