Journal
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
Volume 296, Issue 3, Pages 462-469Publisher
WILEY-BLACKWELL
DOI: 10.1002/ar.22651
Keywords
proteomics; intersexual differences; protein expression; hippocampus
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Funding
- National Natural Science Foundation of China [81200845]
- National Science Foundation for Postdoctoral Scientists of China [20090461301]
- Young Scientist Foundation from the Medical School in Xi'an Jiaotong University [YQN0809]
- Scientific Research Support Program for New Teachers [0116-081410-05]
- Guang Hua Medical Innovation Research Foundation [0203407]
- Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) [1171]
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It is widely accepted that intersexual differences occur in cognitive domains, e. g., in spatial learning and memory. The hippocampus plays important roles in the consolidation of information from short-term memory to long-term memory and spatial navigation. However, it still remains unknown whether the hippocampal proteomic profiling differs between males and females. In this study, we investigated the intersexual differences in protein expression of hippocampi using the two-dimensional electrophoresis analysis. In all, 33 differentially expressed proteins were characterized by matrix-assisted laser desorption and ionization time-of-flight mass spectrometry and validated by Western-blotting analysis. In line with Western-blotting validation, the proteomic identification revealed the overexpression of glial fibrillary acidic protein in female rats' hippocampi, and the overexpression of both creatine kinase B-type and DRP-2 in male rats' hippocampi. The intersexual differences in hippocampal proteomic profiling are probably closely related to those in spatial learning and memory abilities. Anat Rec, 296: 462-469, 2013. (C) 2013 Wiley Periodicals, Inc.
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