Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 42, Issue 6, Pages 1137-1141Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.yjmcc.2007.04.004
Keywords
microRNA; cardiac hypertrophy; miR-21; miR-18b; cardiomyocyte
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Funding
- NHLBI NIH HHS [R01 HL075251-04, R01 HL085635, R01 HL075251] Funding Source: Medline
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MicroRNAs (miRNAs) are a recently discovered class of similar to 22-nucleotide regulatory RNAs that post-transcriptionally regulate gene expression. We have recently demonstrated that muscle-specific miRNAs miR-1 and miR-133 play an important role in modulating muscle proliferation and differentiation. Here, we investigate the involvement of miRNAs in cardiac hypertrophy. We analyzed the global expression of miRNAs in agonist-induced hypertrophic cardiomyocytes as well as in pressure overload-induced hypertrophic hearts and found the miRNA expression profile altered in those hypertrophic conditions. We further show that inhibition of endogenous miR-21 or miR-18b augments hypertrophic growth. Conversely, introduction of functional miR-21 or miR-18b into cardiomyocytes represses myocyte hypertrophy. Together, our studies point to miRNAs as critical regulators of cardiac hypertrophy. (C) 2007 Elsevier Inc. All rights reserved.
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