Journal
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
Volume 295, Issue 11, Pages 1837-1850Publisher
WILEY
DOI: 10.1002/ar.22578
Keywords
aminoglycosides; cisplatin; ototoxicity; oxidative stress; otoprotection
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Funding
- National Institute for Deafness and Communication Disorders, National Institutes of Health [DC 003685, DC 02396]
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This review introduces the pathology of aminoglycoside antibiotic and the cisplatin chemotherapy classes of drugs, discusses oxidative stress in the inner ear as a primary trigger for cell damage, and delineates the ensuing cell death pathways. Among potentially ototoxic (damaging the inner ear) therapeutics, the platinum-based anticancer drugs and the aminoglycoside antibiotics are of critical clinical importance. Both drugs cause sensorineural hearing loss in patients, a side effect that can be reproduced in experimental animals. Hearing loss is reflected primarily in damage to outer hair cells, beginning in the basal turn of the cochlea. In addition, aminoglycosides might affect the vestibular system while cisplatin seems to have a much lower likelihood to do so. Finally, based on an understanding the mechanisms of ototoxicity pharmaceutical ways of protection of the cochlea are presented. Anat Rec, 2012. (C) 2012 Wiley Periodicals, Inc.
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