Journal
ANNALS OF NEUROLOGY
Volume 61, Issue 6, Pages 603-606Publisher
WILEY-LISS
DOI: 10.1002/ana.21138
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Funding
- NIDA NIH HHS [P50DA-05010, P50 DA005010] Funding Source: Medline
- NINDS NIH HHS [R01NS-39961] Funding Source: Medline
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The prevalence of migraine is much greater in female than male individuals. Cortical spreading depression (CSD) is thought to be a fundamental mechanism of migraine, and CSD in rodents is used as a model for migraine. We used optical intrinsic signal imaging and electrophysiological techniques to investigate CSD in C57B1/6 mice. Using two different methods for induction of CSD, we found that female mice had a significantly reduced threshold for induction of CSD compared with male mice. These results suggest an increased cortical excitability in female mice that may be independent of the estrous cycle.
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