Journal
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
Volume 295, Issue 6, Pages 999-1005Publisher
WILEY-BLACKWELL
DOI: 10.1002/ar.22446
Keywords
enriched environment; stereology; myelinated fiber; corpus callosum; aged rat
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Funding
- Natural Science Foundation of China (NSFC) [30973155, 81171238]
- Ministry of Education, P. R. China [200806310007]
- Natural Science Foundation of Chongqing Government (CSTC) [2009BA5035]
- Chongqing Medical University Foundation [XBZD200801]
- Chongqing Medical University
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In this study, the effect of enriched environment (EE) on the spatial learning of aged rats was examined, and then the effects of EE on the aged corpus callosum (CC) were investigated by means of the modern stereological methods. We found that EE significantly improved the spatial learning of aged rats. The CC volume, the total volume of the myelinated fibers and total volume of the myelin sheaths in the CC, the total length of the myelinated fibers in the CC of enriched rats were significantly increased when compared to standard rats. The increase of the myelinated fibers in enriched rat CC might provide one of the structural bases for the enrichment-related improvement of the spatial learning. This study provided, to the best of our knowledge, the first evidence of environmental enrichment-induced increases of the CC and the myelinated fibers in the CC of aged rats. Anat Rec, , 2012. (c) 2012 Wiley Periodicals Inc.
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