Journal
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 74, Issue 1-2, Pages 46-52Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2006.10.004
Keywords
fetal inflammatory process; interluekin-8; preterm birth; term pregnancy; toll-like receptor
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The aim of the study was to investigate the innate immune function of decidual cells from term unlabored pregnancies by determining Toll-like receptor presence and function. Using immunohistochemistry, reverse transcriptase polymerase chain reaction and NF-KB-luciferase plasmid transfection, Toll-like receptor presence and function was determined. Decidual cells express Toll-like receptors 1, 2, 4 and 6 which respond to lipopolysaccharide and peptidoglycan stimulation producing Interleukin-8. Decidual cells from women at term have innate immune function and are capable of producing Interleukin responses to bacterial ligands. (C) 2006 Elsevier Ireland Ltd. All rights reserved.
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