Journal
NATURE CHEMICAL BIOLOGY
Volume 3, Issue 6, Pages 321-322Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio878
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Funding
- NIGMS NIH HHS [GM59907] Funding Source: Medline
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Methods for introducing bioorthogonal functionalities into proteins have become central to protein engineering efforts. Here we describe a method for the site-specific introduction of aldehyde groups into recombinant proteins using the 6-amino-acid consensus sequence recognized by the formylglycine-generating enzyme. This genetically encoded 'aldehyde tag' is no larger than a His(6) tag and can be exploited for numerous protein labeling applications.
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