Journal
CANCER AND METASTASIS REVIEWS
Volume 26, Issue 2, Pages 333-339Publisher
SPRINGER
DOI: 10.1007/s10555-007-9063-1
Keywords
hypoxia; hypoxia-inducible factor; metastasis; angiogenesis; radiotherapy; chemotherapy
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Funding
- NCI NIH HHS [CA67166, CA082566, CA116685, CA123823] Funding Source: Medline
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Hypoxia poses many problems to the treatment of cancer. Hypoxic tumors are more resistant to chemotherapy and radiation. In addition, hypoxia induces a number of genes responsible for increased invasion, aggressiveness, and metastasis of tumors. The augmented metastatic potential due to hypoxia-mediated gene expression is discussed in this section. Particular attention is given to recent studies of specific genes involved in the key steps of metastasis, including extracellular matrix interactions, migration, and proliferation.
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