Journal
PLANTA MEDICA
Volume 73, Issue 6, Pages 572-577Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2007-967196
Keywords
Muntingia calabura; Tiliaceae; dihydrochalcones; 2,3-dihydroxy-4,3 ',4 ',5 '-tetramethoxydihydrochalcone; 4,2 ',4 '-trihydroxy-3 '-methoxydihydrochalcone; flavanone; (2R,3R)-(-)-3,5-dihydroxy-6,7-dimethoxyflavanone; anti-platelet aggregation activity
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Two new dihydrochalcones, 2,3-dihydroxy-4,3,4,5 -tetramethoxydihydrochalcone (1) and 4,2,4 -trihydroxy-3'-methoxydihydrochalcone (2), and a new flavanone, (2R,3R)-(-)-3,5-dihydroxy-6,7-dimethoxyflavanone (3), together with nineteen known compounds have been isolated from the leaves of Muntingia calabura. The structures of three new compounds were determined through spectral analyses including extensive 2D-NMR data. Among the isolates, 2,3-dihydroxy-4,3,4,5 -tetramethoxydihydrochalcone, 5,7-dihydroxy-3-methoxyflavone, 5,7- dihydroxy-6-methoxyflavone, 5,4 -dihydroxy-3,7-dimethoxyflavone, (2S)-7,8,3',4',5'-pentamethoxyflavan, (2S)-5 -hydroxy7,8,3',4 -tetramethoxyflavan, and methyl gallate exhibited significant anti-platelet aggregation activity in vitro.
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