Journal
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
Volume 293, Issue 3, Pages 379-382Publisher
WILEY-LISS
DOI: 10.1002/ar.21080
Keywords
ecto-5 '-nucleotidase; immunohistochemistry; ciliary body; choroid
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Adenosine is known to exert multiple functions within the eye. The aim of this report was to find out if adenosine can be produced locally in the choroid and ciliary body. Therefore, I investigated the distribution of ecto-5'-nucleotidase (5'-NT), the key enzyme for the production of extracellular adenosine. This report provides evidence that 5'-NT is expressed in the choroid and in the ciliary body (and its processes) of the rat eye, predominantly in endothelial cells. These locations of 5'-NT indicate strategically important production sites of adenosine regulating choroid and ciliary body functions (e.g., blood flow, aqueous fluid production, and immune response). Anat Rec, 293:379-382, 2010. (C) 2010 Wiley-Liss, Inc.
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