Journal
GENES CHROMOSOMES & CANCER
Volume 46, Issue 6, Pages 517-521Publisher
WILEY
DOI: 10.1002/gcc.20426
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Activating mutations of the PTPN11 gene encoding the SHP2 tyrosine phosphatase is the most common genetic abnormality in juvenile myelomonocytic leukemia and is sporadically observed in myelodysplasia (MDS) and acute myeloid leukemia (AML). An unselected series of 140 patients with therapy-related MDS or AML were investigated for mutations of PTPN11 in Exons 3, 4, 8, and 13. Four cases had mutations of the gene; three of these had deletions or loss of chromosome arm 7q. Two cases had rare balanced translocations to chromosome band 21q22 with rearrangement of the RUNX1 gene and the other two patients had rare balanced translocations to chromosome band 3q26 with rearrangement of the EV11 gene. The findings support cooperation between so called Class I and Class II mutations in leukemogenesis. (c) 2007 Wiley-Liss, Inc.
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