Journal
SMALL
Volume 3, Issue 6, Pages 956-963Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.200600598
Keywords
atomic force microscopy; biofunctionalization; biomaterials; collagen; self-assembly
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The biofunctionalization of materials creates interfaces on which proteins, cells, or tissues can fulfill native or desired tasks. Here we report how to control the assembly of type I collagen into well-defined nanoscopic matrices of different patterns. Collagen fibrils in these ultrathin (approximate to 3 nm) matrices maintained their native structure as observed in vivo. This opens up the possibility to create programmable biofunctionalized matrices using collagen-binding proteins or proteins fused with collagen-binding domains. Applied to eukaryotic cells, these nanostructured matrices can direct cellular processes such as adhesion, orientation and migration.
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