Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 563, Issue 1-3, Pages 240-244Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2007.02.026
Keywords
histamine H-4 receptor antagonists; JNJ7777120; VUF6002; paw edema; thermal hyperalgesia; carrageenan
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The effects of the highly selective histamine H-4 receptor antagonists JNJ7777120 and VUF6002 were investigated on the carrageenan-induced inflammation and thermal hyperalgesia in rats. JNJ7777120 (10 and 30 mg/kg, s.c.) and VUF6002 (10 mg/kg, s.c.) significantly reduced paw edema and hyperalgesia provoked by subplantar injection of carrageenan; the effect was evident against the early (2 h) phase of inflammation. An inactive analog of VUF6002, VUF6007 (10 mg/kg, s.c.) slightly aggravated paw edema, while leaving unaltered carrageenan-induced nociception. These findings indicate that histamine H4 receptors participate in the early phase of acute inflammation induced by carrageenan in rats, influencing both edema and thermal hyperalgesia. (c) 2007 Elsevier B.V. All rights reserved.
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