Journal
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
Volume 291, Issue 9, Pages 1074-1078Publisher
WILEY
DOI: 10.1002/ar.20754
Keywords
primary cilium; kidneys; cilia
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Funding
- NIGMS NIH HHS [R01 GM052022-13, R01 GM052022] Funding Source: Medline
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The primary cilium is a solitary, immotile cilium that is present in almost every mammalian cell type. Primary cilia are thought to function as chemosensors, mechanosensors, or both, depending on cell type, and have been linked to several developmental signaling pathways. Primary cilium malfunction has been implicated in several human diseases, the symptoms of which include vision and hearing loss, polydactyly, and polycystic kidneys. Recently, primary cilia have also been implicated in the development and homeostasis of the skeleton. In this review, we discuss the structure and formation of the primary cilium and some of the mechanical and chemical signals to which it could be sensitive, with a focus on skeletal biology. We also raise several unanswered questions regal-ding the role of primary cilia as mechanosensors and chemosensors and identify potential research avenues to address these questions.
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