Journal
JOURNAL OF NATURAL PRODUCTS
Volume 70, Issue 6, Pages 1039-1042Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np060477+
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Three new prenylated flavanones, abyssinoflavanones V, VI, and VII (1- 3), together with eight known flavanones (4- 11) and two chalcones (12- 13), were isolated from the stem bark of Erythrina abyssinica. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the isolates, with the exception of 1 and 8, strongly inhibited PTP1B activity in an in Vitro assay with IC50 values ranging from 14.2 +/- 1.7 to 26.7 +/- 1.2 mu M.
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