Journal
CHEMICAL RESEARCH IN TOXICOLOGY
Volume 20, Issue 6, Pages 854-858Publisher
AMER CHEMICAL SOC
DOI: 10.1021/tx6003198
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Dispersion stability of nanoparticles of C-60 under a model condition simulating a physiological environment was studied by dynamic light scattering. Although the C-60 nanoparticles at a concentration of 9.3 x 10(-6) M (6.7 mu g/mL) coagulated and precipitated out rapidly in phosphate buffered saline, coagulation was suppressed completely when HSA was present at concentrations above 1 mg/mL. DLS results show that the HSA molecules adsorb onto the surfaces of the C-60 nanoparticles, thereby forming a protective layer, and prevent salt-induced coagulation. DLS results also indicate that the HSA molecules take an expanded conformation on the surface. Our findings suggest that C-60 nanoparticles can be stabilized in the physiological environment even if they are not deliberately stabilized by using stabilizers and are of significant implications for the on-going efforts to evaluate the cytotoxicity of C-60 nanoparticles in which no such effect has been considered.
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