Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 349, Issue 8-9, Pages 1308-1320Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200700115
Keywords
aldol reaction; asymmetric catalysis; directed evolution; enzyme catalysis
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This review is focused on advances over the last several years in the application of aldolases to organic synthesis. Several new technologies have been implemented to increase the scope and practicality of aldolases as tools for the synthetic chemist. These include directed evolution, discovery of new classes of aldolases in nature and the laboratory, and substrate and reaction engineering. 1 Introduction 2 Directed Evolution and Enzyme Engineering 2.1 DHAP-Dependent Aldolases 2.2 Pyruvate-Dependent Aldolases 2.3 Acetaldehyde-Dependent Aldoases 3, Discovery of Novel Aldolases 4 Reaction and Substrate Engineering 5 Future Prospects and Challenges
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