Journal
AGING CELL
Volume 6, Issue 3, Pages 327-336Publisher
WILEY
DOI: 10.1111/j.1474-9726.2007.00297.x
Keywords
afterhyperpolarization; aging; Alzheimer's disease; hippocampus; learning
Categories
Funding
- NIA NIH HHS [R37 AG08796, AG17139] Funding Source: Medline
- NIMH NIH HHS [MH67251, MH47340] Funding Source: Medline
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Normal aging subjects, including humans, have difficulty learning hippocampus-depenclent tasks. For example, at least 50% of normal aging rabbits and rats fail to meet a learning criterion in trace eyeblink conditioning. Many factors may contribute to this age-related learning impairment. An important cause is the reduced intrinsic excitability observed in hippocampal pyramidal neurons from normal aging subjects, as reflected by an enlarged postburst afterhyperpolarization (AHIP) and an increased spike-frequency adaptation (accommodation). In this review, we will focus on the alterations in the AHIP and accommodation during learning and normal aging. We propose that age-related increases in the postburst AHIP and accommodation in hippocampal pyramidal neurons play an integral role in the learning impairment observed in normal aging subjects.
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