Journal
EXPERIMENTAL PARASITOLOGY
Volume 116, Issue 2, Pages 156-162Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2006.12.004
Keywords
Leishmania major; promastigotes; amastigotes; Leshcutan; Aldara; in vitro and in vivo activity; paromomycin; methylbenzethonium chloride; Imiquimod; balb/c mice, topical treatment
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Paromomycin at 25, 50 and 100 mu g/ml, inhibited the growth of Leishmania major amastigotes by 34.5%, 61.2%, 74.9% and 85.4%, 89.9%, 95.7% on the 2nd and the 4th day of treatment in culture, respectively. Methylbenzethonium chloride at 0.1 and 0.5 mu g/ml and Imiquimod at 5 and 10 mu g/ml, administered separately, inhibited the parasite development by 39.5% and 65.2% and 31.5% and 47.7%, respectively. Imiquimod (5-10 mu g/ml) combined with either paromomycin (25, 50 and 100 mu g/ml) or methylbenzethonium chloride (0.1 and 0.5 mu g/ml) showed an anti-leishmanial additive effect. A 10 day topical treatment, twice daily, with an ointment containing 15% paromomycin and 12% methylbenzethonium chloride (Leshcutan), either undiluted or diluted 1:5 in soft white paraffin combined with 5% Imiquimod cream (Aldara), was as effective as Leshcutan given alone. The present study suggests that a combination of Aldara and-Leshcutan is as effective as Leshcutan given alone in the topical treatment of CL caused by L. major. (c) 2007 Elsevier Inc. All rights reserved.
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