Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 55, Issue 6, Pages 953-954Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.55.953
Keywords
6-hydroxy-5-methylramulosin; sterile mycelium; marine-derived fungus
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(3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin (1) was isolated from a culture of a sterile mycelium, which was derived from the green alga, Codium fragile, along with (-)-5-methylmellein (2), (-)-5-hydroxymethylmellein (3), and (-)-(3R,4R)-cis-4-hydroxy-5-methylmellein (4). The absolute configuration of 1 was determined by the NMR data along with the lactone sector rule by circular dichroism (CD). Compound I exhibited moderate cytotoxic activity against HeLa cells.
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