Journal
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
Volume 13, Issue 1-2, Pages 53-68Publisher
SPRINGER
DOI: 10.1007/s10989-006-9053-0
Keywords
oligonucleotide; non-natural bases; oligonucleotide-peptide conjugates; nanomaterials; self-assembly; solid phase synthesis
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Synthetic oligonucleotides are ubiquitously found in most laboratories since solid-phase synthesis protocols have become highly optimized. These protocols make it possible to synthesize a large variety of modified oligonucleotides. As one example, we will review some of the developments regarding oligonucleotide synthesis from our own group. In particular, we will describe the synthesis of oligonucleotides carrying non-natural bases, of oligonucleotide-peptide conjugates, and of modified oligonucleotides used in the assembly of nanomaterials.
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