Journal
AMERICAN JOURNAL OF PSYCHIATRY
Volume 164, Issue 6, Pages 861-867Publisher
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.ajp.164.6.861
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Funding
- NCRR NIH HHS [M01-RR-00054] Funding Source: Medline
- NIA NIH HHS [AG-21790, AG-022476] Funding Source: Medline
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High levels of homocysteine are associated with cerebrovascular disease, monoamine neurotransmitters, and depression of mood. A plausible hypothesis for these associations is that high homocysteine levels cause cerebral vascular disease and neurotransmitter deficiency, which cause depression of mood. The homocysteine depression hypothesis, if true, would mandate inclusions of imaging studies for cerebrovascular disease and measures of homocysteine, folate, and B-12 and B-6 vitamins in the clinical evaluation of older depressed patients. Longitudinal studies and clinical trials should be designed to challenge the hypothesis.
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