Journal
MEMORIAS DO INSTITUTO OSWALDO CRUZ
Volume 102, Issue 4, Pages 531-534Publisher
FUNDACO OSWALDO CRUZ
DOI: 10.1590/S0074-02762007005000032
Keywords
astrovirus type 8; molecular characterization; Belem; Brazil
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This study describes the genetic relationships of the first human astrovirus type-8 ( HAstV-8) detected in Belem-Brazil, during a public hospital-based study. This strain was compared with other HAstV-8 strains identified elsewhere which have sequences available at GeneBank. The regions ORF1a (primers Mon348/Mon340) and ORF2 (primers Mon269/Mon270) were analyzed by nucleotide sequencing and a high similarity rate was observed among the Belem strain and other HAstV-8 strains. In ORF1a, homology values of 93-100% were detected, and in ORF2 96-99%. Considering the sequence variation (7%) observed in ORF2 region, it was suggested that HAstV-8 strains could be divided in three different lineages.
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